Wu, C.C.#, Jeratsch, S., Graumann, J. and Stainier, D.Y.R.# (2020) # Corresponding authors
Mammalian cardiomyocyte polyploidy research to date has mostly focused on the cell-autonomous regulation. In this work, we found that the postnatal extracellular matrix provides a non-permissive environment for cardiomyocyte cytokinesis. We further identified specific ECM components that are able to promote cardiomyocyte cell division.
Bertozzi, A.*, Wu, C.C.*, Dalvoy, M., Nguyen, P., Koopman, C., de Boer, T., Bakkers, J. and Weidinger, G. (2021) * Equal Contribution
The regenerative capacity of the zebrafish heart has long been documented. However, how fast and to what extent the zebrafish heart regenerates are not clear. In this work, we showed for the first time that zebrafish cardiomyocyte number returns to pre-injury level 30 days post cryoinjury, much quicker than scar resolution. Intriguingly, complete regeneration is also observed in hearts which retain a fibrotic scar, suggesting that myocardial regeneration and scarring are not mutually exclusive.
Wu, C.C.*, Kruse, F.*, Dalvoy, M, Junker, J.P., Zebrowski, D.C., Fischer, K., Noël, E.S., Grün, D., Berezikov, E., Engel, F.B., van Oudenaarden, A., Weidinger, G. and Bakkers, J. (2016) * Equal Contribution
A fruitful collaboration with the Bakkers lab in which we generated the first genome-wide transcriptom of the regenerating zebrafish heart with high spatial resolution using Tomo-seq, a technique developed by the Bakkers lab. From this dataset, we further identified the important role of BMP signaling in zebrafish cardiomyocyte dedifferentiation, proliferation, and regeneration.
Beisaw, A., Kuenne, C., Günther, S., Dallmann, S., Wu, C.C., Bentsen, M., Looso, B. and Stainier, D.Y.R. (2020)
Chromatin landscape changes in regenerating zebarfish cardiomyocytes is driven by AP-1 transcription factors. We overexpressed several AP-1 family members and found that they are sufficient to promote proliferation and migration of mammalian cardiomyocytes.
Schnabel, K.*, Wu, C.C.*, Kurth, T., Weidinger, G. (2011) * Equal Contribution
This study will always be special for me: my very first first-author publication. We established a cryoinjury method for adult zebrafish heart, and it has since been widely used in the field!
Full publication list at Google Scholar.