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MODULATION OF MAMMALIAN CARDIOMYOCYTE CYTOKINESIS BY THE EXTRACELLULAR MATRIX.  CIRCULATION RESEARCH 127:896-907.

Wu, C.C.#, Jeratsch, S., Graumann, J. and Stainier, D.Y.R.# (2020) # Corresponding authors

Mammalian cardiomyocyte polyploidy research to date has mostly focused on the cell-autonomous regulation.  In this work, we found that the postnatal extracellular matrix provides a non-permissive environment for cardiomyocyte cytokinesis.  We further identified specific ECM components that are able to promote cardiomyocyte cell division.

IS ZEBRAFISH HEART REGENERATION ‘COMPLETE’? LINEAGE-RESTRICTED CARDIOMYOCYTES PROLIFERATE TO PRE-INJURY NUMBERS BUT SOME FAIL TO DIFFERENTIATE IN FIBROTIC HEARTS. DEVELOPMENTAL BIOLOGY 471, 106-118.

Bertozzi, A.*, Wu, C.C.*, Dalvoy, M., Nguyen, P., Koopman, C., de Boer, T., Bakkers, J. and Weidinger, G. (2021) * Equal Contribution

The regenerative capacity of the zebrafish heart has long been documented.  However, how fast and to what extent the zebrafish heart regenerates are not clear. In this work, we showed for the first time that zebrafish cardiomyocyte number returns to pre-injury level 30 days post cryoinjury, much quicker than scar resolution.  Intriguingly, complete regeneration is also observed in hearts which retain a fibrotic scar, suggesting that myocardial regeneration and scarring are not mutually exclusive.

SPATIALLY-RESOLVED GENOME–WIDE TRANSCRIPTIONAL PROFILING IDENTIFIES BMP SIGNALING AS ESSENTIAL REGULATOR OF ZEBRAFISH CARDIOMYOCYTE REGENERATION.  DEVELOPMENTAL CELL 36, 36-49.

Wu, C.C.*, Kruse, F.*, Dalvoy, M, Junker, J.P., Zebrowski, D.C., Fischer, K., Noël, E.S., Grün, D., Berezikov, E., Engel, F.B., van Oudenaarden, A., Weidinger, G. and Bakkers, J. (2016) * Equal Contribution

A fruitful collaboration with the Bakkers lab in which we generated the first genome-wide transcriptom of the regenerating zebrafish heart with high spatial resolution using Tomo-seq, a technique developed by the Bakkers lab.  From this dataset, we further identified the important role of BMP signaling in zebrafish cardiomyocyte dedifferentiation, proliferation, and regeneration.

AP-1 CONTRIBUTES TO CHROMATIN ACCESSIBILITY TO PROMOTE SARCOMERE DISASSEMBLY AND CARDIOMYOCYTE PROTRUSION DURING ZEBRAFISH HEART REGENERATION.  CIRCULATION RESEARCH 126:1760–1778.

Beisaw, A., Kuenne, C., Günther, S., Dallmann, S., Wu, C.C., Bentsen, M., Looso, B. and Stainier, D.Y.R. (2020)

Chromatin landscape changes in regenerating zebarfish cardiomyocytes is driven by AP-1 transcription factors.  We overexpressed several AP-1 family members and found that they are sufficient to promote proliferation and migration of mammalian cardiomyocytes.

REGENERATION OF CRYOINJURY INDUCED NECROTIC HEART LESIONS IN ZEBRAFISH IS ASSOCIATED WITH EPICARDIAL ACTIVATION AND CARDIOMYOCYTE PROLIFERATION.  PLOS ONE. 6(4), E18503.

Schnabel, K.*, Wu, C.C.*, Kurth, T., Weidinger, G. (2011) * Equal Contribution

This study will always be special for me: my very first first-author publication.  We established a cryoinjury method for adult zebrafish heart, and it has since been widely used in the field!

Full publication list at Google Scholar.

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